Thrombocytopenia

Management of thrombocytopenia with ENHERTU1

Thrombocytopenia can occur in patients treated with ENHERTU.1

  • Of the 184 patients with unresectable or metastatic HER2+ breast cancer who received ENHERTU 5.4 mg/kg in DESTINY-Breast01, the incidence of platelet count decrease2
    • Grade 1 incidence 9.8%; Grade 2 incidence 4.3%; Grade 3 incidence 3.3%
  • Based on the severity of thrombocytopenia, manage through treatment interruption or dose reduction1

Dose modifications for thrombocytopenia1

Severity Treatment Modification
Grade 3
(platelets less than 50 to 25 x 109/L)
  • Interrupt ENHERTU until resolved to Grade 1 or less, then maintain dose
Grade 4
(platelets less than 25 x 109/L)

Toxicity grades are in accordance with the National Cancer Institute—Common Terminology Criteria for Adverse Events Version 4.03 (NCI-CTCAE v.4.03).

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